Osteoprotective action of low-salt diet requires myeloid cell–derived NFAT5
نویسندگان
چکیده
منابع مشابه
Low Salt Diet and Insulin Resistance
It is well known that high sodium intake is closely associated with the risk of cardiovascular disease, but the effect of low sodium intake on insulin resistance is not clear. In this article, we summarize findings from previous studies focusing on the association between low sodium intake and insulin resistance. While many investigations on this topic have been conducted actively, their major ...
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Accumulating evidence shows an increase in insulin resistance on salt restriction. We compared the effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertensive subjects. We also evaluated the relationship between salt sensitivity of blood pressure and salt sensitivity of insulin resistance in a multivariate regression model. Studies were conducted after 1 w...
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NFκB is a central mediator of inflammation. Present inhibitors of NFκB are mostly based on inhibition of essential machinery such as proteasome and protein kinases, or activation of nuclear receptors; as such, they are of limited therapeutic use due to severe toxicity. Here we report an LPS-induced NFκB enhanceosome in which TonEBP is required for the recruitment of p300. Increased expression o...
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The BPs of 86 of 100 severely hypertensive patients were controlled by measures designed to reduce total body sodium, namely a low salt diet plus the addition of incrementally increased frusemide treatment if diet alone was inadequate. Control of hypertension was maintained over prolonged periods of time in 70 of the patients. Among the 14 who failed to respond adequately, mean plasma renin lev...
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Hypertension is a common health problem. Hypotensive drugs and low salt diet are used in its treatment. This study was designed to compare the effectiveness of a low-salt diet and drug therapy in the treatment of arterial hypertension. A total of 256 randomly selected patients with essential hypertension consulting the Non-contagious Diseases Clinic in Shahreza, Isfahan, Iran, were included...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2019
ISSN: 2379-3708
DOI: 10.1172/jci.insight.127868